临床与实验病理学杂志2013，Vol.29Issue(4)：385-388,4.
液泡型ATP酶C亚基ATP6V0C在人前列腺癌细胞系中的表达及其意义
Expression of C subunit of vacuolar ATPase and its significance in prostate cancer cell lines
摘要
Abstract
Purpose To investigate the expression and significance of C subunit of vacuolar ATPase ( ATP6V0C ) in human prostate cancer cell lines with different metastatic potential.Methods The expression of ATP6V0C was evaluated in different prostate cancer cell lines using RT-PCR, real-time RT-PCR and Western blot.Results The expression of ATP6V0C mRNA and protein in PC-3M-1E8 and PC-3M cell line with high metastatic potentiality was significantly higher than that in PC-3M-2B4 and PC-3 cell line with low metastatic potential.Of them all, the expression of ATP6V0C in PC-3M-1E8 was highest.Conclusion The expression of ATP6V0C in PC-3M-1E8 and PC-3M cell line with high metastatic potential is significantly higher than that in PC-3M-2B4 and PC-3 cell line with low metastatic potential, suggesting that ATP6V0C is closely related to prostate cancer metastasis.Therefore, ATP6V0C is an important prognostic indicator in judgement of prostate cancer cell growth, progression and metastasis, and targeting ATP6V0C may be a promising strategy against human prostate cancer.关键词
前列腺肿瘤/ATP6V0C/液泡型ATP酶/转移Key words
prostate neoplasms /ATP6V0C/vacuolar ATPase/metastasis分类
医药卫生引用本文复制引用
邹鹏程,徐晓艳,张梦雪,由江峰,裴斐..液泡型ATP酶C亚基ATP6V0C在人前列腺癌细胞系中的表达及其意义[J].临床与实验病理学杂志,2013,29(4):385-388,4.基金项目
国家自然科学基金面上项目(30971142) （30971142）
