山东医药2013，Vol.53Issue(15)：23-25,3.DOI:10.3969/j.issn.1002-266X.2013.15.008
血小板活化因子乙酰水解酶基因型与变应性鼻支气管炎的相关性
Correlation of platelet-activating factor acetylhydrolase and its genotype with allergic rhino-bronchitis
摘要
Abstract
Objective To investigate the correlation of platelet-activating factor acetylhydrolase ( PAF-AH) and its genotype with allergic rhino-bronchitis ( ARB). Methods The genotype of plasmatic PAF-AH at exon ninth 994 locus was examined by allele specific polymerase chainreaction (AS-PCR) and the allele frequency was calculated in patients with allergic rhino-bronchitis ( case group) and healthy controls ( control group) . Results No differences were found on the genotype and allele frequencies between case and control groups ( P > 0. 05 ). There were statistical differences related to the genotypes among allergic rhinitis (AR) , AR with bronchial asthma (BA) , AR with airway hyperresponsiveness ( AHR) and control groups (all P < 0. 05). There were also significant differences associated with the allele frequencies among AR, AR with BA, AR with AHR and control groups (all P<0.05). Conclusion There are some correlations between the allele gene mutation of plasmatic PAF-AH and ARB.关键词
血小板活化因子/乙酰水解酶/基因型/变应性鼻支气管炎Key words
platelet-activating factor/acetylhydrolase/genotype/allergic rhino-bronchitis分类
医药卫生引用本文复制引用
张再兴,王彦君,宁树成,戴建军,刘广伟,赵君晖..血小板活化因子乙酰水解酶基因型与变应性鼻支气管炎的相关性[J].山东医药,2013,53(15):23-25,3.基金项目
河北省科技厅科技支撑计划项目(09276101D-40). （09276101D-40）
