陕西医学杂志2013，Vol.42Issue(5)：515-517,3.
白藜芦醇对小鼠辐射氧化损伤的保护性研究
The protective effects of resveratrol on irradiation induced oxidative damage in mice
摘要
Abstract
Objective: To study the protective effects of resveratrol on irradiation induced damage in the mice and its probable mechanism . Methods : The mice received 6Gy total body irradiation . The SOD , Mn-SOD , and CAT activity in plasma , and the CAT in the BMMC were detected .Result :①The Mn-SOD activity in the Rev group was lower than that in the control group(P<0.05), the total SOD had slight variation ; Compared to the irradiated mouse, the total SOD activity in the Rev + IR group increased significantly (P<0 .05 ), suggesting that Rev could decrease Mn-SOD activity , but not the total SOD . ② Rev increased CAT in the plasma and BMMC (.P<0 .05), compared to the irradiated group , the CAT activity in the Rev + IR group increased significantly (P<0 .05 ) . Conclusion : Resveratrol has protective effects on the oxidative damage induced by irradiation exposure , and its mechanism is probably to promote the peroxidase activity .关键词
氧化剂/损伤/创伤和损伤/治疗/酚类/治疗应用/动物,实验/小鼠Key words
Oxidants/injuries /Wounds and injuries/therapy/ Phenols/therapeutic use/ Animals ,laboratory / Mice分类
医药卫生引用本文复制引用
李程程,张恒,吴红英,王营营,黄颂,张珠博,孟爱民..白藜芦醇对小鼠辐射氧化损伤的保护性研究[J].陕西医学杂志,2013,42(5):515-517,3.基金项目
国家自然科学基金海外合作基金(No 81129020) （No 81129020）
天津市重点基金(No 11JCZDJC19100) （No 11JCZDJC19100）
国家973重大专项(No2011CB964 800-G) （No2011CB964 800-G）
国家自然科学基金面上项目(No 81072237) （No 81072237）
