摘要
Abstract
Objective : To observe the clinical therapeutic efficiency of Xuebijing injection and Ulinastatin on severe pneumonia treatment. Methods :237 cases were randomized into control group , Xuebijing group, Ulinastatin group, Xuebijing and Ulinastatin combination group .It's detected the protein content/ plasma proteins of bron-choalveolar lavage fluid (BALF) ,neutrophils numbers and inflammatory factor IL-6 concentration ,also monitored PaO2 and P(A-a)O2 of blood gas analysis , pulmonary compliance changes by end-tidal airway occlusion technique before and after 1,2 weeks in the experiment ,for the lung function recoverd evaluation .Results : Four groups of patients bronchoscopy lung lavage fluid IL-6 after 2 weeks of treatment were 159 .3±11 .4 ng / L, 143 ,1 i 9 ,9 ng/L , 139 .1 ± 7 .8ng/L , 125 .7±11 .8ng/L , neutral Granular cell numbers were 9 .4±0 .9 ,8 .9 ± 0 .8 ,8 .3 ± 0 .5 ,7 .9 ± 0 . 8 , albumin concentration / serum albumin were 0 .72±0 .06 , 0 .66±0 .05 , 0 .59 ± 0 .03 ,0 .51 ± 0 .06 , lung compli-anceas 199 .89±12 .79 ,203 .99±12 .88 ,205 .87±11 .97 ,213 .85±11 .19 , blood gas analysis of oxygen partial pressure were 105 .3 ± 14 .5 ,101.3±5 .7 ,107 .9±4 .9 ,115 .3±11 .9 , alveolar - arterial oxygen difference were 13 .8±3 . 1,15 .3±3 .5 , 13 .1±4 .7 , 10 .1 ± 1 .9 .Four groups of patients was compared in lung lavage fluid IL-6 , neutrophil cells , albumin concentration / serum albumin, alveolar - arterial oxygen difference were significantly decreased (P <0.05) , lung compliance ,blood oxygen partial pressure were significantly higher (P <0 .05) , and prompted lung function improved significantly , but the best effect to the combination therapy group .Conclusion : The combination group is more effective in the treatment of severe pneumonia ,and the causes are relevant to potent anti-infection ,the body oxygen improvement and capillary permeability reduction .关键词
肺炎/药物疗法/抗生素/治疗应用Key words
Pneumonia/drug therapy / Antibiotics/therapeutic use
分类
医药卫生
