陕西医学杂志2013，Vol.42Issue(5)：613-615,3.
小儿川崎病38例外周血糖皮质激素受体检测及其临床意义
周南 1王涛 1苏德成 1高晓鹏 1王娟莉 1王嵩1
作者信息
摘要
Abstract
Objective : To investigate the change of glucocorticoid receptor including glucocorticoid recep -tor-α (GR-α) and glucocorticoid receptor-β(GR-β) in peripheral blood in patients with Kawasaki disease (KD), for provide a theoretical basis of the glucocorticoid (GC ) therapy . Methods : The levels of GR-a and GR-β were measured using ELISA respectively in 38 patients with KD before and after IVIG and 20 healthy children (control group) . Results : There was no difference in the level of GR-a in KD patients and the control group (P>0 .05), But it was significantly lower (P< 0 .01) at 3 and 7 days after intravenous immunoglobulin(IVIG) . Before and after IVIG , the GR-β levels were significantly lower in KD patients than in the control group (P < 0 .01). The level of GR-aand GR-βdiffered between patients with and without dilated coronary arteries . Conclusion : The results suggest that exogenous glucocorticoid can play an important role in the process of anti-inflammatory in the acute KD .关键词
黏膜皮肤淋巴结综合征/血液/受体,糖皮质激素/代谢/儿童Key words
Mucocutaneous lymphynode syndrome /blood / Receptors ,glucocorticoid/metabolism / Child
分类
医药卫生引用本文复制引用
周南,王涛,苏德成,高晓鹏,王娟莉,王嵩..小儿川崎病38例外周血糖皮质激素受体检测及其临床意义[J].陕西医学杂志,2013,42(5):613-615,3.
