中国临床药理学与治疗学2013，Vol.18Issue(3)：252-257,6.
海马神经元型一氧化氮合酶神经元再生通路介导5-羟色胺类抗抑郁药作用
Hippocampal nNOS-neuronal regeneration pathways mediates the effect of 5-serotonin antidepressive drugs
摘要
Abstract
To explore the antidepressive mechanism of serotonin reuptake inhabitor and selective 5-HT1A receptor agonist. METHODS: Fluoxetine, a serotonin reuptake inhibitor, and 8-OH-DPAT, a selective 5-HT1A receptor agonist, were infused into the dentate gy-rus (DG) of bilateral hippocampus of nNOS knockout and wild-type mice by stereotactic surgery. Brdu immunohistochemisty was performed to detect neurogenesis as well as novelty suppressed feeding test, forced swimming test and tail suspending test were used to measure de-
pression-related behavior. RESULTS;Both selective infusion of fluoxetine and 8-OH-DPAT into hippocampus up-regulated neurogenesis and generated antidepressant- like effect, which were dependent on the function of nNOS. CONCLUSION: nNOS-neurogenesis cascade in the hippocampus mediates the antidepressive effect of serotonin reuptake inhabitor and selective 5-HT1A receptor agonist.关键词
抑郁症/氟西汀/选择性5-HT1A受体激动剂/神经元再生/神经元型一氧化氮合酶Key words
Depession/ Fluoxetine/ Selective 5-HT1A receptor agonist/Neurogenesis/ nNOS分类
医药卫生引用本文复制引用
吴海银,张晶..海马神经元型一氧化氮合酶神经元再生通路介导5-羟色胺类抗抑郁药作用[J].中国临床药理学与治疗学,2013,18(3):252-257,6.
