中国临床药理学与治疗学2013，Vol.18Issue(3)：282-285,4.
拟康氏木霉胞外多糖抗肿瘤活性研究
Experimental study on anti-tumor activity of extracellular polysaccharides from Trichoderma pseudokoningii
摘要
Abstract
To study antitumor effect of extracellular polysaccharides from Trichoderma pseudokoningii. METHODS: In vitro , we studied the antitumor activity of TPeps on human leukemia HL-60 cells with MTT, and in vivo, TPeps were intragastrically given to mice with S180 solid tumor at the dose of 50, 100 and 200 mg·kg-1 · d-1· Normal sodium and cyclophos-phamide were taken as blank control and positive control respectively. The tumor weight, spleen index, thymus index and the relative growth rate were measured. RESULTS: TPeps could significantly inhibit HL-60 cells proliferation in a time and concentration dependent manner. Meanwhile, compared with control TPeps three dose groups significantly decreased the weight of tumor, increased the spleen index and thymus index(P<0. 05, P < 0.01). However, TPeps had no discernible effect on the relative growth rate. CONCLUSION: TPeps have a certain a-mount of anti-tumor action.关键词
拟康氏木霉/胞外多糖/抗肿瘤/人白血病细胞HL-60/肉瘤S180Key words
Trichoderma pseudokoningii/ Exopolysaccharides/ Antitumor effect/ Human leukemia HL-60 cells/ Sarcoma-180分类
医药卫生引用本文复制引用
李丽华,陈靠山,喻丽珍,卜晓阳..拟康氏木霉胞外多糖抗肿瘤活性研究[J].中国临床药理学与治疗学,2013,18(3):282-285,4.基金项目
安徽省高校自然科学研究基金项目(KJ2012Z424) （KJ2012Z424）
