中国临床药理学与治疗学2013，Vol.18Issue(3)：325-330,6.
组蛋白去甲基化酶JMJD1A及其生物学功能研究进展
Histone demethylase JMJD1A and its biological functions
摘要
Abstract
Histone demethylase JMJD1A (Jumonji domaincontaining protein 1A) regulates gene transcription by hydroxylation pathway, which demethylases mono- and di-methy H3K9 (H3K9mel/2). JMJD1A play roles in spermatogenesis, energy metabolism, regulation of stem cell as well as the initiation and progress
of cancer. Here, we review the structure, catalytic mechanism, substrate specificity, biological function and inhibitor of JMJD1A.关键词
JMJD1A/基因转录调控/组蛋白去甲基化酶Key words
JMJD1A/ Histone demethylase/ Gene transcriptional regulation分类
医药卫生引用本文复制引用
湛敏,周宏灏..组蛋白去甲基化酶JMJD1A及其生物学功能研究进展[J].中国临床药理学与治疗学,2013,18(3):325-330,6.
