中国临床药理学杂志2013，Vol.29Issue(4)：260-262,3.
口服利伐沙班预防人工全髋关节置换术后深静脉血栓的临床研究
Clinical study of deep venous thrombosis prevention after total hip arthroplasty with oral rivaroxaban
杨礼庆 1王程 1沈涛 1焦士军 1付勤1
作者信息
摘要
Abstract
Objective To evaluate the effectiveness and safety of oral rivaroxaban ( Xarelto ) with nadroparin ( Fraxiparine) for preventing venous thromboembolism ( VTE) after total hip arthroplasty. Methods One hundred and forty five patients matched with the inclusion criteria with primary total hip arthroplsty were randomly divided into 2 groups. Rivaroxaban group (75 cases) took oral rivaroxaban 10 mg once daily for 10 days after operation, while LMWH(low molecular weight heparin) group (70 cases) took subcutaneous injection of 0. 4 mg once daily for 10 days after operation. Deep venous thrombosis ( DVT) were examined by the color doppler ultrasonic in 7 ~ 10 days after operation. Bleeding was observed after operation. Drainage volume were calculated within 48 hours after removal of the drainage tube. The variation values of coagulation parameters were observed at 7 th day after operation. Results Deep venous thrombosis, bleeding tendency and drainage volume showed no statistically significant difference between the two groups after operations. Pro-thrombin time(PT) of rivaroxaban group was prolonged at 7 th day after operation comparing with preoperation. International normalized ratio ( INR) of both groups showed no significant change at 7 th day after operation comparing with preoperation. Conclusion Comparing with LMWH , rivaroxaban had the same effectiveness to prevent DVT after total hip joint arthroplasty. There had no major bleeding events in two groups.关键词
人工全髋关节置换术/深静脉血栓/利伐沙班Key words
total hip arthroplasty/deep venous thrombosis,rivaroxaban分类
医药卫生引用本文复制引用
杨礼庆,王程,沈涛,焦士军,付勤..口服利伐沙班预防人工全髋关节置换术后深静脉血栓的临床研究[J].中国临床药理学杂志,2013,29(4):260-262,3.
