中国输血杂志2013，Vol.26Issue(3)：119-122,4.
异基因造血干细胞移植治疗急性白血病28例临床分析
Analysis of allogenetic hematopoietic stem cell transplantation for the treatment of 28 patients with acute leukemia
摘要
Abstract
Objective To evaluate the clinical curative effect of allogeneic hematopoietic stem cell transplantation ( allo-HSCT) for acute leukemia ( AL). Methods Twenty-eight patients with AL, including 7 cases with acute lymphoblastic leu-kemia(ALL) ,and 21 cases with acute myeloid leukemia (AML), received the treatment of allo-HSCT with HLA matched sibling donors except 2 cases(5/6 matched) in our hospital from January 2005 to August 2011. Twenty-two patients were preconditioned with busulfan(Bu) and cyclophosphamide(Cy) regimen,3 patients with modified Bu/Cy regimen,3 patients with fludarabine(F)/Bu/Cy regimen. The routine prevention of graft versus host disease (GVHD) consisted of methotrexate (MTX) and cyclosporine A (CsA). Results All patients were quickly achieved hematopoietic reconstitution after allo-HSCT. The median follow-up duration was 22 months. At the end of follow-up, overall survival (OS) was 71.4% , among them, 16 patients (57. 1% ) survived with disease-free survival (DFS) in 11 to79 months after allo-HSCT. There was no GVHD presented ,6 patients had chronic GVHD. Eight patients were respectively died of cGVHD, relapse or progression of infection and disease after transplantation. The patients who had complete remission after the first chemotherapy (CR1) a-chieved higher overall survival rate and disease-free survival rate after transplantation than those who had complete remission after the second chemotherapy(CR2) or none remission(NR) patients during the same period. Conclusion Allo-HSCT is an effective method for treatment of AL, and the patients should adopt allo-HSCT as soon as possible after the CR1.关键词
异基因/外周血造血干细胞移植/急性白血病Key words
allogeneic/ hematopoietic stem cell transplantation/ acute leukemia分类
医药卫生引用本文复制引用
王先选,王利,肖青,王建渝,张红宾,唐晓琼,王欣,杨泽松,陈建斌..异基因造血干细胞移植治疗急性白血病28例临床分析[J].中国输血杂志,2013,26(3):119-122,4.基金项目
重庆市自然科学基金(2009JJ0424) （2009JJ0424）
