中国中医药信息杂志2013，Vol.20Issue(1)：49-51,3.DOI:10.3969/j.issn.1005-5304.2013.01.019
枳朴方中空栓对术后肠麻痹大鼠肠道屏障功能的影响
Effect of Zhipu Recipe Hollow-type Suppositories on Intestinal Barrier Function in Postoperative Enteroparalysis Rats
摘要
Abstract
Objective To observe the effect of Zhipu Recipe hollow-type suppositories (ZRHTS) on intestinal flora and apoptosis rate of colonic epithelia in postoperative enteroparalysis rats, and probe into its mechanism. Methods Fifty male SD rats were randomly divided into blank control group, model group, bifid tripleviable group, high-dose ZRHTS group, low-dose ZRHTS group. The postoperative enteroparalysis model was built by removing the uterus. The changes of escherichia coli, bacillus bifidus and apoptosis rate of colonic epithelia were observed two days after modeling. Results Compared with the blank control group, the content of escherichia coli was higher, and bacillus bifidus in the model group was obviously lower (P<0.01). In high-dose ZRHTS group, escherichia coli was lower and bacillus bifidus was higher than those of the model group (P<0.01). Compared with the blank control group, the apoptosis rate of colonic epithelia in the model group was obviously higher (P<0.01). Apoptosis rate of colonic epithelia in high-dose ZRHTS group was lower than that of the model group (P<0.01). Conclusion ZRHTS can improve intestinal flora disturbance and apoptosis rate of colonic epithelia in postoperative enteroparalysis rats, which may contribute to its preventive and therapeutic mechanism.关键词
枳朴方中空栓/术后肠麻痹/肠道菌群/肠上皮细胞凋亡率/大鼠Key words
Zhipu Recipe hollow-type suppositories/ postoperative enteroparalysis/ intestinal flora/apoptosis rate of colonic epithelia/ rats分类
医药卫生引用本文复制引用
张慧玲,武玉鹏,白崇智,张恒..枳朴方中空栓对术后肠麻痹大鼠肠道屏障功能的影响[J].中国中医药信息杂志,2013,20(1):49-51,3.基金项目
山西省科技攻关项目(20090311055-3) （20090311055-3）
