中国中医药信息杂志2013，Vol.20Issue(3)：19-21,25,4.DOI:10.3969/j.issn.1005-5304.2013.03.009
IgA肾病中医证候分型与临床及病理的相关性
Relevance of TCM Syndrome Types of Primary IgA Nephropathy with Clinical Manifestation and Pathological Changes
摘要
Abstract
Objective To study and discuss the relevance of TCM syndrome types of primaiy IgA nephropathy with clinical manifestation and pathological change, identify the relationship between the macro manifestation and micro changes of kidney. Methods The clinical and pathological data of 120 patients diagnosed as primary IgA nephropathy with renal biopsy were collected. The relevance of TCM syndrome with clinical indicator and pathological indexes was analyzed. Results In TCM syndrome types, deficiency in both qi and yin had the largest proportion. The urea nitrogen content of spleen-kidney yang deficency was higher than that of lung-kidney qi deficiency, and its creaunine clearance rate was lower than that of lung-kidney qi deficiency, spleen-kidney qi deficiency and deficiency in both qi and yin, moreover, its serum creatinine and 24 h urine protein were higher than the other four types. The score of interstitial inflammatory cell infiltration and renal tubular atrophy score of liver-kidney yin deficiency syndrome, glomerular atrophy score and the total score of deficiency syndrome in both qi and yin were higher than that of spleen-kidney qi deficiency. There was relevance between interstitial inflammatory cell infiltration and the thickening of blood vessel wall. Deficiency in both qi and yin had positive relation to glomerular hyperplasia. Spleen-kidney yang deficiency was related to interstitial fibrosis, renal tubular atrophy and thickening of blood vessel wall. Conclusion To some extent, the clinical and pathological deterioration of IgA nephropathy reflect the evolution process of TCM syndrome from spleen (lungVkidney qi deficiency to deficiency in both qi and yin, liver-kidney yin deficiency and spleen-kidney yang deficiency. There is relevance of TCM syndrome types with clinical manifestation and pathological changes.关键词
IgA肾病/证候/临床表现/病理改变Key words
IgA nephropathy/ syndrome/ clinical manifestation/ pathological change分类
医药卫生引用本文复制引用
陈明,万廷信,戴恩来..IgA肾病中医证候分型与临床及病理的相关性[J].中国中医药信息杂志,2013,20(3):19-21,25,4.基金项目
甘肃卫生行业科研计划(GSWST2010-12) （GSWST2010-12）
