北京大学学报（医学版）2013，Vol.45Issue(2)：207-210,4.DOI:10.3969/j.issn.1671-167X.2013.02.009
血浆前白蛋白联合C-反应蛋白对川崎病患儿冠状动脉病变的预测
Plasma prealbumin and C-reactive protein predicts coronary artery lesions in children with Kawasaki disease
张春雨 1刘丽丽 1廖莹 1杜军保 1金红芳1
作者信息
摘要
Abstract
Objective:To study the changes of plasma prealbumin (PA) and C-reactive protein (CRP) in children with Kawasaki disease, and to explore the importance of integral analysis of plasma PA and CRP in predicting the severity of coronary artery lesions in Kawasaki Disease. Methods: In a retrorespec-tive study, 108 children with Kawasaki disease admitted in our hospital were enrolled. The statistical methods included t test, Chi-square test, and ROC curve analysis. The changes of plasma PA and CRP during the disease were studied. Also, the usefulness of comprehensive analysis of PA and CRP in predicting the severity of coronary artery lesions was also evaluated. Results: During the acute phase of Kawasaki disease, the plasma PA level was decreased distinctly, while the CRP level increased significantly. Among the 55 cases whose plasma PA level was <80 mg/L, setting CRP = 76. 5 mg/L as the cutoff value, the occurrence of coronary artery dilations for those with CRP level <76. 5 mg/L was significantly higher than those with CRP level >76.5 mg/L (P <0.05). Conclusion: Plasma PA and CRP changed greatly during the process of Kawasaki disease. And it may be of importance in predicting the severity of coronary artery lesions, by using integrated plasma PA and CRP.关键词
前白蛋白/C-反应蛋白/黏膜皮肤淋巴结综合征/冠状动脉疾病Key words
Prealbumin/C-reactive protein/ Mucocutaneous lymph node syndrome/Coronary disease分类
医药卫生引用本文复制引用
张春雨,刘丽丽,廖莹,杜军保,金红芳..血浆前白蛋白联合C-反应蛋白对川崎病患儿冠状动脉病变的预测[J].北京大学学报（医学版）,2013,45(2):207-210,4.
