北京大学学报（医学版）2013，Vol.45Issue(2)：238-241,4.DOI:10.3969/j.issn.1671-167X.2013.02.015
脓毒症患者中血清程序化细胞死亡因子5水平的変化
Serum level of programmed cell death 5 protein levels in patients with sepsis
刘慧琳 1田勍 1洪天配 1刘桂花 1潘欢 1王海宁 1高洪伟1
作者信息
摘要
Abstract
Objective:To investigate the changes of serum programmed cell death 5 (PDCD5) levels in patients with critical illnesses including systemic inflammatory response syndrome ( SIRS, except sepsis) , sepsis (except severe sepsis) and severe sepsis. Methods: A total of 78 patients were enrolled in this study, of whom, 28 were with SIRS, 23 with sepsis and 27 with severe sepsis. Twenty-two healthy individuals were included as controls. The levels of serum PDCD5 were evaluated by enzyme-linked immune sorbent assay. And the correlation analyses were made in the levels of sreum PDCD5 and acute physiology and chronic health evaluation Ⅱ ( APACHE Ⅱ ) , high-sensitivity C-reactive protein ( hs-CRP) , white blood cell count, neutrophil count and age factors. Results: Serum PDCD5 levels in the SIRS, sepsis and severe sepsis groups were ( 19. 07 ±8. 91) , (29. 03 ± 13. 27) and (42. 83 ± 17. 32) μg/L respectively, which were significantly higher than that in the healthy control group (0.32 ±0.02) μg/L. Serum PDCD5 levels in SIRS, sepsis and severe sepsis groups were gradually increased with significant difference at any in-between comparison (P <0. 05). Moreover, serum PDCD5 levels were positively correlated with the acute physiology and chronic health evaluation Ⅱ ( APACHE Ⅱ ) score (r =0.572, P<0. 05). Conclusion: The serum PDCD5 levels in the critically ill patients with sepsis were progressively increased with the worsened condition. The up-regulated expression of PDCD5 may play an important role in the development and progression of sepsis.关键词
PDCD5蛋白,人/脓毒症/细胞凋亡/全身炎症反应综合征Key words
PDCD5 protein, human/ Sepsis/ Apoptosis/ Systemic inflammatory response syndrome分类
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刘慧琳,田勍,洪天配,刘桂花,潘欢,王海宁,高洪伟..脓毒症患者中血清程序化细胞死亡因子5水平的変化[J].北京大学学报（医学版）,2013,45(2):238-241,4.
