北京大学学报（医学版）2013，Vol.45Issue(2)：323-326,4.DOI:10.3969/j.issn.1671-167X.2013.02.032
补体系统调控异常与C3肾小球病
Complement system regulation and C3 glomerulopathy
摘要
Abstract
Complement system is a key system for immune surveillance and homeostasis. Excessive activation of complement system, especially the activation of alternative pathway may play a very important role in the pathogenesis of primary and secondary glomerulonephritis. C3 glomerulopathy is a newly named disease characterized by evident C3 deposition in the glomeruli with little or no immunoglobulin under immunofluorescence (IF). Its clinical and pathological manifestations vary a lot. The decreased plasma C3 and Factor H( FH) suggest that abnormal regulation of complement system plays an importment role in its pathogenesis. C3 glomerulopathy varies a lot as to its clinical manifestation, treatment and prognosis. The inhibition of excessive complement activation might be the key to treating C3 glomerulopathy.关键词
补体C3/补体激活/肾小球肾炎Key words
Complement C3 / Complement activation/ Glomerulonephritis分类
医药卫生引用本文复制引用
肖慧捷,何瑞娟..补体系统调控异常与C3肾小球病[J].北京大学学报（医学版）,2013,45(2):323-326,4.
