重庆医学2013，Vol.42Issue(12)：1362-1364,3.DOI:10.3969/j.issn.1671-8348.2013.12.017
内毒素性急性肺损伤小鼠肺组织中P38MAPK的表达
Expression of P38 MAPK in lung tissue of mice with endotoxin-induced acute lung injury
摘要
Abstract
Objective To investigate the expression of P38 MAPK in endotoxin induced acute lung injury(ALI). Methods The ALI model was set up by intraperitoneal injection of 20 mg/kg lipopolysaccharide(LPS). Blood samples were collected for blood gas analysis, lung samples were for histomorphology changes. The expressions of phosphated p38 MAPK in lung tissues were detected by immunohistochemistry and Western blot. Results The positive expressions of phosphated P38 MAPK distribute mainly in infil trative inflammatory cells,epithelial cells and endothelial cells. And the levels of expression of phosphated P38 MAPK in ALI group were higher obviously than those in control group,peeking at two hour. Conclusion P38 MAPK signal transduction pathway was activated in endotoxin induced ALI.关键词
急性肺损伤/脂多糖/P38丝裂原活化蛋白激酶Key words
acute lung injury/ lipopolysaccharide/ P38 mitogen activated protein kinase引用本文复制引用
秦开秀,王勇,简华刚..内毒素性急性肺损伤小鼠肺组织中P38MAPK的表达[J].重庆医学,2013,42(12):1362-1364,3.
