基础医学与临床2013，Vol.33Issue(4)：396-399,4.
新疆地区哈萨克族心房颤动与钾离子通道KCNE1-G38S基因多态性的相关性
Xinjiang Kazak people's atrial fibrillation is related with potassium ion channel KCNE1-G38S genetic polymorphism
摘要
Abstract
Objective To study if Xinjiang Kazak people's atrial fibrillation is related with potassium channels KCNEl-G38S gene polymorphisms. Methods The blood was Collected from Kazak people in xinjiang region with atrial fibrillation (af) and control group, both included 100 cases. DNA was extracted, polymerase chain reaction-restriction enzyme fragment length polymorphism ( PCR-RFLP) was used and identified by agarose electrophoresis to analyse KCNEl-G38S genotype and allele distribution. Results KCNE1-G38S gene AA, AG, GG genotype frequency were found respectively in atrial fibrillation group 0. 13(13/100) , 0. 34(34/100) and 0.53(53/100) , and in the control group 0. 10 (10/100) , 0. 57(57/100) and 0. 33(33/100) , two groups of genotype distribution were statistically significant differences ( P < 0. 05 ) , and atrial fibrillation group G allele frequency (0. 70) was much higher than those in the control group (0. 515) (P <0. 001 ). Conclusions In Xinjiang Kazak people the occurrence of af is related with KCNEl-G38S gene polymorphism is related, and which may have race, regional differences.关键词
心房颤动/KCNE1/基因多态性/种族Key words
atrial fibrillation/KCNE1 /gene polymorphism/ racial分类
医药卫生引用本文复制引用
马晓芸,木胡牙提,卢武红,杨玉春,南岳龙..新疆地区哈萨克族心房颤动与钾离子通道KCNE1-G38S基因多态性的相关性[J].基础医学与临床,2013,33(4):396-399,4.基金项目
国家自然科学基金(81060017) （81060017）
