基础医学与临床2013，Vol.33Issue(4)：429-433,5.
ACE、CYP11B2和α-ADDUCIN基因多态性与福建汉族高血压相关性的分析
Association between ACE, CYP11B2 and α-ADDUCIN gene polymorphisms and hypertension in fujian chinese population
摘要
Abstract
Objective The aim is to investigate the association between ACE, CYP11B2 and α-ADDUCIN gene polymorphisms and primary hypertensive subjects. Methods A total of 1380 essential hypertension and 888 normal controls were surveyed in Fujian Chinese population. The genotype for ACE, CYP11B2 and α-ADDUCIN were determined by polymerase chain reaction ( PCR) and restriction fragment length polymorphism ( RFLP). Results In multigene analysis,the frequencies of ACE-DD +ADDUCIN-TT genotype and ACE-DD + CYP11B2-TC/CC genotype were significantly higher in hypertension group than in control group (P <0. 05 ) ,OR(95% CI) were 1. 81 ( 1. 09, 3. 01) (P <0. 05) and 1. 61 (1. 15,2. 27) (P <0. 01) respectively;the frequencies of ACE-DD + CYP11B2-TC/CC + ADDUCIN-TT genotype was significantly higher in hyperten-sion group than control group (P <0. 05) ,OR(95% CI) was 2. 82 (1. 41 - 5. 65), (P < 0. 01). Conclusions The combined genotype ACE-DD, ADDUCIN-TT and CYP11B2-TC/CC might be related with hypertension. It is possible that multigenes were interacted in the etiology of hypertension.关键词
血管紧张素转换酶/醛固酮合成酶/α-内收蛋白/基因多态性/原发性高血压Key words
angiotensin converting enzyme ( ACE)/ aldosterone synthase ( CYP11B2) / α-ADDUCIN/ gene polymorphism/ primary hypertension分类
医药卫生引用本文复制引用
林慧中,陈慧,吴小盈,陈燕,李德育,陈喜军..ACE、CYP11B2和α-ADDUCIN基因多态性与福建汉族高血压相关性的分析[J].基础医学与临床,2013,33(4):429-433,5.基金项目
福建省自然科学基金重点资助项目(C0420003) （C0420003）
