基础医学与临床2013，Vol.33Issue(4)：439-443,5.
ACE/DD基因型和MYH7突变与原发性高血压左室肥厚的关系
Relationship between MYH7 gene mutation and the ACE/DD genotype and LVH in essential hypertension
摘要
Abstract
Objective To investigate whether MYH7 gene mutation and the ACE/DD genotype were associated with left ventricular hypertrophy ( LVH) in Chinese essential hypertension. Methods We conducted a case-control study on 303 volunteers, 102 hypertensive with LVH and 101 hypertensive without LVH and 100 normal controls. Echocardiography measurement and calculation of left ventricular mass index (LVMI). Polymerase chain reaction ( PCR) .restriction fragment length polymorphism ( RFLP) detection ACE/DD genotype, double deoxidizing end sequencing method to detect MYH7 genetic mutations. Results In LVH group, ACE gene frequency DD genotype was significantly higher than the hypertensive but without LVH group and the normal control group (P <0. 01 ) ; MYH7 gene mutation is not found. Conclusions ACE gene polymorphism has significant relationship with high blood pressure LVH, DD genotype vulnerable to left ventricular hypertrophy. MYH7 gene mutations and hypertensive with LVH have no significant relationship, no evidences are found to support the association between the ACE/ DD genotype as well as MYH7 gene mutation and LVH in essential hypertension.关键词
高血压/左心室肥厚/基因多态性/基因突变Key words
essential hypertension/ left ventricular hypertrophy/ gene polymorphism/ gene mutations分类
医药卫生引用本文复制引用
郭军霞,高东升,甘立军,代玉川,李传方..ACE/DD基因型和MYH7突变与原发性高血压左室肥厚的关系[J].基础医学与临床,2013,33(4):439-443,5.基金项目
山东省教育厅科技计划项目(J11LF59) （J11LF59）
