生殖医学杂志2013，Vol.22Issue(4)：237-241,5.DOI:10.3969/j.issn.1004-3845.2013.04.006
促/抑炎因子平衡在反复胚胎种植失败中的作用
Effect of pro-inflammatory and anti-inflammatory cytokine balance on recurrent implantation failure
摘要
Abstract
The balance of pro-inflammatory and anti-inflammatory cytokine plays a significant role on the process of embryo implantation and pregnancy. However, the imbalance of these cytokines is probably one of the most important causes of recurrent implantation failure. On one hand,the higher pro-inflammatory cytokine or insufficient anti-inflammatory cytokine may activate the immune cells(NK cell, macrophage and T cell) at the fetal-maternal interface, which probably attacks the trophoblast cells and promotes the formation of thrombus in the villous vessels,thus leads to the immunological rejection to the fetus, implantation failure, early pregnant loss and contributes to the pregnancy complication such as intrauterine growth retardation, preeclampsia and preterm labor. On the other hand, lower pro-inflammatory cytokine or higher anti-inflammatory cytokine may influence the embryo adhesion to endometrium and angiogenesis, which results in implantation failure. In conclusion, the bias of the pro-inflammatory or anti-inflammatory cytokine is probably detrimental to uterine receptivity and implantation.关键词
反复种植失败/促炎因子/抑炎因子/子宫内膜容受性Key words
Recurrent implantation failure/ Pro-inflammatory cytokine/ Anti-inflammatory cytokine/ Uterine receptivity引用本文复制引用
梁佩燕,李观贵,连若纯,陈晓燕,曾勇..促/抑炎因子平衡在反复胚胎种植失败中的作用[J].生殖医学杂志,2013,22(4):237-241,5.基金项目
广东省医学科学技术研究基金(B2012331) （B2012331）
