中国免疫学杂志2013，Vol.29Issue(3)：243-246,4.DOI:10.3969/j.issn.1000-484X.2013.03.005
IL-17、IL-6和TGF-β在子宫内膜异位症患者组织的表达
Positive expressions of IL-17, IL-16 and TGF-β in endometriosis tissues
摘要
Abstract
Objective:To investigate the positive expressions of interleukins(IL) 17 and IL-6, and transforming growth factor (TGF)β in Endometriosis(EMs) and the role in pathogenesis of EMs. Methods:Expressions of IL-17 and 6,and TGF-β were detected by immunohistochemistly (Elivision two-step) in 35 cases of ectopic endometrium tissues, 20 cases of eutopic endometrium tissues and 15 cases of normal endometrium tissues( control group). Results:The positive ratio of IL-17 in ectopic endometrium tissues(85. 7% ) was significantly higher than that in eutopic endometrium tissues (20. 0%) ( P < 0. 01) and in control group (6. 7%)(P<0. 01), and there was no significant difference between eutopic endometrium group and control group. The positive ratio of IL-6 in ectopic endometrium tissues(60. 0% ) was significantly higher than that in control group( 13. 3% ) (P <0. 01) ,and the positive ratio in eutopic endometrium tissues was 40. 0% , compared with the other two group there was no significant difference. The positive ratio of TGF-(Jin ectopic endometrium tissues(97. 1%) was significantly higher than that in eutopic endometrium tissues(20. 0% ) (P< 0.01) and in control group( 13. 3% ) (P <0. 01) ,and there was no significant difference between eutopic endometrium group and control group. Three cyto-kines had no high positive expression in healthy controls. Expressions of IL-6 and TGF-β had positive correlation with that of IL-17 in ectopic endometrium tissues(r =0. 91,0. 97,P <0. 01 ). Conclusion:IL-17 and IL-6,and TGF-β may play promoting role in the occurrence and development of EMs.关键词
白细胞介素17/白细胞介素6/转化生长因子β/子宫内膜异位症/免疫组织化学Key words
Interleukin(IL) 17/Interleukin( IL) 6/ Transforming growth factor (TGF) beta /Endometriosis( EMs) /Immuno-histochemistry分类
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冯春蝶,王福玲,袁芳,林伟..IL-17、IL-6和TGF-β在子宫内膜异位症患者组织的表达[J].中国免疫学杂志,2013,29(3):243-246,4.
