中国药房2013，Vol.24Issue(15)：1360-1362,3.DOI:10.6039/j.issn.1001-0408.2013.15.06
灯盏乙素苷元对帕金森病模型大鼠多巴胺能神经元的保护作用研究
Study on the Protective Effects of Scutellarein on Dopaminerigic Neurons of PD Model Rats
摘要
Abstract
OBJECTIVE: To explore the protective effect of scutellarein on dopaminerigic neurons of parkinson' s disease(PD) model rats. METHODS: PD rat models were induced by stereotaxic injection of LPS. Model rats were divided into 7 groups, i.e. blank control group (constant volume of normal saline), sham operation group (constant volume of normal saline), model group (constant volume of normal saline), Madopar group (0.034 mg/kg) and scutellarein high-dose, medium-dose and low-dose groups (800, 400, 200 mg/kg). They were given medicine intragastrically once a day for consecutive 3 weeks. Apomorphine (apo) was injected subcutaneously on the rat back to observe praxiology of it. The levels of MDA, SOD and GSH were determined. RESULTS: Compared with model group, rotational speed of rats were decreased significantly in scutellarein high-dose, medium-dose and low-dose groups(P<0.05); GSH and SOD levels were increased significantly, while MDA level was decreased significantly(P< 0.01 or P<0.05). CONCLUSION: Scutellarein can improve rotation behavior of PD model rats and the ability of anti-oxidation of dopaminergic neurons and protect the central nervous system of PD rats.关键词
灯盏乙素苷元/脂多糖/帕金森病/多巴胺能神经元/大鼠Key words
Scutellarein/ Lipopolysaccharide/ Parkinson's disease/ Dopaminerigic neurons/ Rat分类
医药卫生引用本文复制引用
郭晓红,刘颖,刘辉..灯盏乙素苷元对帕金森病模型大鼠多巴胺能神经元的保护作用研究[J].中国药房,2013,24(15):1360-1362,3.
