中国药房2013，Vol.24Issue(15)：1362-1364,3.DOI:10.6039/j.issn.1001-0408.2013.15.07
β-七叶皂苷钠在家兔体内的药动学研究
Pharmacokinetics Study of β-aescin Sodium in Rabbits
摘要
Abstract
OBJECTIVE: To establish a method for the concentration determination of β-aescin sodium in blood of rabbits. METHODS: ELISA method was adopted. The blood concentration of β-aescin sodium in normal rabbits and cerebral ischemia-reper-fusion rabbits were determined after i.v. injection of β-aescin(5 mg/kg). The pharmacokinetic parameters were analyzed. RESULTS: After i.v. injection of β-aescin sodium, main pharmacokinetic parameters of normal rabbits vs. model rabbits were as follows: t1/2α were (0.343 ± 0.061) h vs. (0.854 ± 0.079) h;t1/2β were (23.325 ± 10.36) h vs. (34.283 ± 13.74) h; CL were (1.600 ± 1.206) L/h vs. (0.718±0.428) L/h; Vd were (53.827±36.42) L vs.( 14.799± 10.15) L; AUCo0-24h were (2.919±0.981) μg/(h·L) vs.(26.417± 9.207) μg/(h·L); AUG0-∞ were (3.126 ± 1.253) μg/(h·L) vs.(27.848 ± 8.745)μg/(h·L);Cmax were(4.126 ± 0.927) mg/L vs. (7.905 ± 1.054) mg/L. CONCLUSION: The elimination of β-aescin sodium in cerebral ischemia-reperfusion rats is slower than in normal rats, remain inside the body for a long time. The pharmacokinetic characteristics of β-aescin should be considered in the clinical symptomatic treatment.关键词
β-七叶皂苷钠/家兔/药动学Key words
β-aescin sodium/ Rabbits/ Pharmacokinetics分类
医药卫生引用本文复制引用
罗宁,张斯汉,颜晗,赵奎..β-七叶皂苷钠在家兔体内的药动学研究[J].中国药房,2013,24(15):1362-1364,3.
