中国医科大学学报2013，Vol.42Issue(4)：304-306,3.
新型羟基磷灰石涂层镁合金生物学毒性及相容性观察
The Observation of Biology Cytotoxicity and Biocompatibility of the New Magnesium Alloy with HA Coated
摘要
Abstract
Objective To appraise cytotoxicity and biocompatibility of Mg-4.0Zn-0.5Sr alloy and Mg-4.0Zn-1.5Sr alloy,respectively. Methods Both of the magnesium alloy with hydroxyapatite (HA) coated were prepared firstly,then the extracts of the alloy samples were picked-up to determine the magnesium ion concentration, and through the cultivated of the fibroblasts L929, the cell vigor of MTT colorimetry assessment and hemolysis ratio were obtained. Results The pH of the extract of Mg-4.0Zn-1.5Sr alloy is higher than that of Mg-4.0Zn-0.5Sr alloy (P < 0.05),but the magnesium ion concentration of Mg-4.0Zn-1.5Sr alloy is lower than that of Mg-4.0Zn-0.5Sr alloy, as well as both of the relative growth rate (RGR) are similar and the hemolysis ratio of Mg-4.0Zn-1.5Sr alloy is lower than that of Mg-4.0Zn-0.5Sr alloy (P < 0.05). Through 24 h,48 h and 72 h cultivated,the count of L929 cell is shown that both counts of the alloys are decreased slightly and there are not marked difference compared with the comparison group. Conclusion Because the cytotoxicity of both Mg-4.0Zn-0.5Sr alloy and Mg-4.0Zn-1.5Sr alloy is not shown and there is a better biocompatibility,the further study is needed.关键词
镁合金/生物学/毒性/相容性/羟基磷灰石Key words
magnesium alloy/ biology/ cytotoxicity/ biocompatibility/ hydroxyapatite分类
医药卫生引用本文复制引用
秦海明,陈渝宁,宋福林,崔彤,管仁国..新型羟基磷灰石涂层镁合金生物学毒性及相容性观察[J].中国医科大学学报,2013,42(4):304-306,3.基金项目
国家自然科学基金资助项目(51074049) （51074049）
国家自然科学基金研究重点项目(51034002) （51034002）
