摘要
Abstract
Objective To compare the effects of esomeprazole and omeprazole in the treatment of reflux esophagitis. Methods Ninety cases of reflux esophagitis treated in this hospital were collected randomly divided into two groups. The control group (42 cases) was given oral omeprazole 40 mg, once daily at 30 min before breakfast, while the treatment group (48 cases) was given oral esomeprazole 40 mg, once daily at 30 min before breakfast. The two groups were treated for 8 weeks. The clinical efficacy, clinical symptom scores before and after treatment, endoscopic esophagitis improvement situation and the adverse reactions were observed and compared between the two groups. Results The total effective rate was 76. 19% in the control group and 91.67% in the treatment group, the difference between the two groups showing statistical significance (P < 0. 05). The symptom scores after treatment were obviously decreased compared with the before treatment, but the decrease in the treatment group was more significant than that in the control group with statistical difference (P < 0. 05). Endoscopic esophagitis after treatment was improved, but the treatment group was significantly superior to the control group, the difference between the two groups was statistically significant (P < 0.05). The treatment group had 1 case of nausea and vomiting, 1 case of abdominal pain, while the control group had 3 cases of headache, 1 case of nausea and 5 cases of diarrhea. The symptoms were mild, did not affect the continued treatment, and disappeared after medication discontinuation. The liver and kidney functions, routine of blood, urine and stool before and after treatment showed no abnormality. Conclusion Esomeprazole and omeprazole have the significant effect in the treatment of reflux esophagitis, can effectively alleviate the clinical symptoms with less adverse reactions. But esomeprazole is superior to omeprazole in the clinical efficacy, and a safe and effective drug for treating reflux esophagitis, which deserves to be popularized in clinic.关键词
埃索美拉唑/奥美拉唑/反流性食管炎Key words
esomeprazole/ omeprazole/ reflux esophagitis分类
医药卫生
