中国中医药信息杂志2013，Vol.20Issue(2)：43-45,3.DOI:10.3969/j.issn.1005-5304.2013.02.014
淫羊藿苷治疗去势大鼠骨质疏松症基因表达谱分析
Analysis of Genes Expression Profiles of Icariin in Treating Osteoporosis of Ovariectomized Rats
摘要
Abstract
Objective To investigate the mechanism of icariin in treating osteoporosis of ovariectomized with gene chips technology. Method A total of 20 female SD rats were randomly divided into model group and treatment group, 10 rats in each group. After ovariectomized to make model, treatment group was given icariin [aqueous phase 0.4 mL/(100 g · d), oil phase 0.6 mL/(100 g · d)J, model group was given the same volume water and vegetable oil once per day for 13 weeks. Gene chips of RatRef-12-v 15590097019 were used to investigate the gene expression profile of osteoporosis rats, and the different expressed genes were analyzed with Gene Ontology. Results A total of 532 significant differentially expressed genes related were detected. Among them, 175 genes were up-regulated, 357 genes were down-regulated. Conclusion Many genes differential expression are related with icariin in treating osteoporosis of ovariectomized rats.关键词
淫羊藿苷/去势大鼠/骨质疏松症/基因表达谱Key words
icariin/ ovariectomized rats/ osteoporosis/ gene expression profiles分类
医药卫生引用本文复制引用
高峰,莫新民,李劲平..淫羊藿苷治疗去势大鼠骨质疏松症基因表达谱分析[J].中国中医药信息杂志,2013,20(2):43-45,3.基金项目
国家自然科学基金(30873291) （30873291）
