中国中医药信息杂志2013，Vol.20Issue(2)：65-67,3.DOI:10.3969/j.issn.1005-5304.2013.02.024
化瘀祛痰颗粒质量标准研究
Study on Quality Standard of Huayu Qutan Granules
摘要
Abstract
Objective To establish the quality control standard of Huayu Qutan granules. Methods The TLC method was applied to identify Codonopsis pilosula, Astragalus mongholicus, Fiveleaf Gynostemma Herb and Curcuma aromatica. The content of Salvianolic acid B was determined by HPLC. Experiment was carried out on Diamonsil C18 column with mobile phase consisted of methanol-acetonitrile-methane acid-water (30 : 10 : 1 : 59) at a flow rate of 1.0 mL/min. The detection wavelength was at 286 nm and the column temperature was 30℃. Result The TLC spots were clear and distinguished well, and the negative sample didnt interfere the identification of TLC. Salvianolic acid B showed a good linear relationship with its peak area in the range of 0.142 5-1.4250 μg (r=0.999 7). The average recovery rate was 98.45% and RSD was 1.99%. Conclusion The method is reliable, specific and reproducible, so it can be used for quality control of Huayu Qutan granules.关键词
化瘀祛痰颗粒/薄层色谱法/高效液相色谱法/质量标准Key words
Huayu Qutan granules/ TLC/ HPLC/ quality standard分类
医药卫生引用本文复制引用
贾连群,杨关林,陈阳,任路,张哲,张会永..化瘀祛痰颗粒质量标准研究[J].中国中医药信息杂志,2013,20(2):65-67,3.基金项目
中国博士后科学基金特别资助项目(201104611) （201104611）
中国博士后科学基金面上项目(20090451279) （20090451279）
辽宁省高等学校杰出青年学者成长计划(LJQ2011100) （LJQ2011100）
