南方医科大学学报2013，Vol.33Issue(3)：382-385,4.DOI:10.3969/j.issn.1673-4254.2013.03.15
动脉瘤性蛛网膜下腔出血后慢性脑积水与TGF-β1的关系及相关多因素分析
Association of chronic hydrocephalus after aneurysmal subarachnoid hemorrhage with transforming growth factor-β1 levels and other risk factors
摘要
Abstract
Objective To study the role of transforming growth factor-β1 (TGF-β1) levels and other risk factors in the occurrence of chronic hydrocephalus after aneurysmal subarachnoid hemorrhage (aSAH). Methods Patients treated for aSAH in our hospital between January, 2007 and June, 2012 were divided into non-hydrocephalus group and hydrocephalus group. TGF-β1 levels in the cerebrospinal fluid (CSF) were compared between the two groups at different time points. A retrospective analysis was conducted to identify the potential risk factors for chronic hydrocephalus, which were subsequently confirmed by Logistic regression analysis. Results Of the 129 patients enrolled, 16 (12.4%) developed chronic hydrocephalic with an average diagnosis time of 31.6±17.0 days. In patients with chronic hydrocephalus, TGF-β1 level in the CSF increased significantly on the 13th day following aSAH (P<0.05). Retrospective analysis showed that the patients with hydrocephalus and those without had significant differences in history of hypertension, times of SAH, Hunt-Hess classification, ventricular expansion, aneurysm position, Fisher classification, ventricular hemorrhage score and intracranial infections (P<0.05). Logistic regression analysis identified ventricular expansion, aneurysm position, Fisher classification, ventricular hemorrhage score and postoperative intracranial infections as significant risk factors for the occurrence of chronic hydrocephalus (P<0.05). Conclusions In adult patients with aSAH, the risk factors for chronic hydrocephalus include ventricular expansion, aneurysm position, Fisher classification, ventricular hemorrhage score and postoperative intracranial infections. These risk factors can have greater clinical value than TGF-β1 levels in the CSF in predicting the occurrence of chronic hydrocephalus following aSAH.关键词
慢性脑积水/动脉瘤性蛛网膜下腔出血/转化生长因子-β1/危险因素Key words
chronic hydrocephalus/ aneurysmal subarachnoid hemorrhage/ transforming growth factor-β1/ risk factors引用本文复制引用
刘飞,袁文,廖达光,张天一,王知非..动脉瘤性蛛网膜下腔出血后慢性脑积水与TGF-β1的关系及相关多因素分析[J].南方医科大学学报,2013,33(3):382-385,4.基金项目
湖南省科技计划项目(2012FJ4311)(2012FJ3125) （2012FJ4311）
