南方医科大学学报2013，Vol.33Issue(3)：424-427,4.DOI:10.3969/j.issn.1673-4254.2013.03.24
中国重型血友病A的临床表现异质性及早期预测指标
Clinical predictors for the phenotypic heterogeneity of severe hemophilia A in China
摘要
Abstract
Objective To observe the phenotypic heterogeneity of severe hemophilia A in China and investigate the clinical factors for defining the severity of the clinical presentations. Methods The data including the age of first bleeding and first joint bleeding, bleeding frequency, the number of joint deformities and body mass index (BMI) were collected from 223 patients with severe hemophilia A (FVⅢ:C≤2%). Results The median age at first bleeding was 1 year (range: 0-35 years). The percentages of patients with first bleeding age<1 year, ≥2 years and ≥6 years were 44.3% (94/212), 34.4% (73/212), and 10.8% (23/212), respectively. The median age at first joint bleeding was 2.25 years. The percentages of patients with first joint bleeding age ≤1 year, ≥ 2 years and ≥ 6 years were 25.5% (24/94), 57.4% (54/94), and 18.1% (17/94), respectively. The percentage of patients who did not have joint bleeding was 7.4% (7/94). The median annual bleeding frequency was 24 per year (range: 1-120), and the proportion of patients with annual bleeding episodes of less than 6 times was 12.9%. Only 24.7% of the patients were free of any joint deformities. Analysis showed that milder cases had older ages of first bleeding and first joint bleeding than the severe cases, and the milder cases had also significantly lower BMI. Conclusion The age of first bleeding and first joint bleeding and BMI may predict the clinical severity of hemophilia A in China in the early stage.关键词
血友病A/重型血友病/临床表现异质性/体质量指数Key words
hemophilia A/ severe hemophilia/ phenotypic heterogeneity/ body mass index引用本文复制引用
李含,孙竞,周璇,刘阳,宋晓玲,马庆辉..中国重型血友病A的临床表现异质性及早期预测指标[J].南方医科大学学报,2013,33(3):424-427,4.基金项目
广东省自然科学基金(S2011010003897) （S2011010003897）
