国际医药卫生导报2013，Vol.19Issue(7)：907-910,4.DOI:10.3760/cma.j.issn.1007-1245.2013.07.007
ROC曲线评价毛细管区带电泳用于α地中海贫血筛查的临床价值
Application of ROC cureves to assess the clinical value of capillary zone electrophoresis for screening alpha-thalassemia
周远青 1梁瑞莲 1谢健敏 1梁玉全 1罗建伟 1陈映慧 1黎运西 1曾淑英1
作者信息
摘要
Abstract
Objective To explore the clinical value of capillary zone electrophoresis for screening alpha-thalassemia and to ascertain the cutoff value of HbA2 for the diagnosis of alpha-thalassemia.Methods 66 alpha-thalassemia patients (alpha-thalassemia group) and 86 healthy controls (control group) were enrolled in this study.Hemoglobin capillary zone electrophoresis and detection of alpha-thalassemia gene were arried out in both groups.The receiver operating characteristic curve (ROC) was used to assess the value of HbA2 for the diagnosis of alpha-thalassemia and the cut-off value of HbA2 were ascertained.Statistical analysis was performed with the SPSS 17.0 statistical software.Results HbA2 level was (2.65 ± 0.29)％ in the control group and (2.ββ + 0.22)％ in alpha-thalassemia group,with a significant difference (P＜0.01).HbA2 level was lower in alpha-thalassemia group than in the control group.The area under receiver operating characteristic curve (AUC) of HbA2 was 0.804 (SE:0.0β5,95％ CI:0.7β6-0.872) for diagnosis of alpha-thalassemia,and the diagnostic value had significant differences (P＜0.01),with an optimal cut-off value of 2.55％.HbA2 showed a diagnostic sensitivity of 60.5％ and specificity of 89.4％.Conclusions Hemoglobin capillary zone electrophoresis for HbA2 detection is a better method for screening alpha-thalassemia at present and has a higher clinical value.关键词
ROC曲线/血红蛋白电泳/毛细管区带电泳/α地中海贫血/诊断Key words
ROC curves/ Hemoglobin electrophoresis/ Capillary zone electrophoresis/ Alpha-thalassemia/ Diagnosis引用本文复制引用
周远青,梁瑞莲,谢健敏,梁玉全,罗建伟,陈映慧,黎运西,曾淑英..ROC曲线评价毛细管区带电泳用于α地中海贫血筛查的临床价值[J].国际医药卫生导报,2013,19(7):907-910,4.
