国际病理科学与临床杂志2013，Vol.33Issue(2)：116-119,4.DOI:10.3969/j.issn.1673-2588.2013.02.005
三氧化二砷对原发性肝癌经肝动脉化学治疗栓塞术后血管内皮生长因子表达的影响
Effect of arsenic trioxide on vascular endothelial growth factor after transarterial chemoembolization in primary carcinoma of liver
张海波 1黄力建 1朱燕娟 1李勇 1白建平 1潘宗奇 1孟凡哲1
作者信息
摘要
Abstract
Objective:To observe the effect of arsenic trioxide on vascular endothelial growth factor (VEGF) after
transarterial chemoembolization in primary carcinoma of liver. Methods:We prospectively studied 30 consecutive primary carcinoma of liver patients after transarterial chemoembolization (TACE), who were randomly divided into a treatment group and a control group. Arsenic trioxide was injected intravenously in patients in the treatment group (n=15), while saline was injected in those in the control group (n=15). The VEGF in serum was tested before TACE and 3, 8, or 16 days after TACE. Results:Compared with that before TACE, the VEGF in serum
raised significantly 3 days and 8 days after TACE both in the 2 groups. The VEGF level was not significantly different between the 2 groups (P>0.05). However, the VEGF level decreased significantly 16 days after TACE in the treatment group, while the VEGF level still raised in the control group (P<0.01). Conclusion:Arsenic trioxide may reduce the VEGF level in serum after TACE.关键词
原发性肝癌/经肝动脉化学治疗栓塞/三氧化二砷/血管内皮生长因子Key words
hepatocellular carcinoma/transarterial chemoembolization/arsenic trioxide/vascular endothelial growth factor引用本文复制引用
张海波,黄力建,朱燕娟,李勇,白建平,潘宗奇,孟凡哲..三氧化二砷对原发性肝癌经肝动脉化学治疗栓塞术后血管内皮生长因子表达的影响[J].国际病理科学与临床杂志,2013,33(2):116-119,4.
