国际病理科学与临床杂志2013，Vol.33Issue(2)：165-169,5.DOI:10.3969/j.issn.1673-2588.2013.02.015
Keap1-Nrf2-ARE通路与慢性阻塞性肺疾病氧化/抗氧化失衡关系
Relation between Nrf2-Keap1-ARE signaling pathway and imbalance of COPD oxidation/anti-oxidation
摘要
Abstract
Chronic obstructive pulmonary disease (COPD) is a kind of common disease, which displays incompletely reversible airflow limitation. The imbalance of oxidation/anti-oxidation is the one of the major pathogenesis of COPD. Keapl-Kelch-like ECH-associated protein 1-Nrf2 (NF-E2-related factor2)-ARE (antioxidant response element) (Keapl-Nrf2-ARE) is a novel defensive pathway involved in oxidative stress of organism. It is important to explore the molecular structures of Keapl-Nrf2-ARE, the regulatory mechanisms of phase II detoxifying enzyme genes expression and how to the correct the imbalance of the oxidation/anti-oxidation in COPD.关键词
慢性阻塞性肺疾病/氧化应激/Keap1-Nrf2-ARE通路/抗氧化Key words
chronic obstructive pulmonary disease/oxidative stress/Keap 1 -Nrf2-ARE pathway/anti-oxidation引用本文复制引用
姜敏,高振,李风森..Keap1-Nrf2-ARE通路与慢性阻塞性肺疾病氧化/抗氧化失衡关系[J].国际病理科学与临床杂志,2013,33(2):165-169,5.基金项目
新疆维吾尔自治区自然科学基金(2012211B35). （2012211B35）
