中医学报2013，Vol.28Issue(5)：681-682,前插1,3.
温补肾阳汤早期干预对哮喘小鼠EOS祖细胞分化的影响
Effect on EOS Differentiation of Progenitor Cell in Asthmatic Mice by the Intervention of Wenbu Shenyang Tang
摘要
Abstract
Objective:To observe the influence of wenbu shenyang tang ( WBSYT)on the EOS differentiation of progenitor cells in asthmatic mice,and explore its possible mechanism. Methods:All 30 BALB / c mice were randomly equally divided into three groups;blank control group,model group and WBSYT group. All groups were treated at the beginning of modeling,once daily for 29 days. Peripheral blood IgE, IL-5 , Eotaxin, pathological changes of lung tissue, and the express of the EOS, CD34+cell, CD34 + /CCR3 + cells in the bone marrow suspension were observed. Results:Compared with model group,the mice peripheral blood IgE,IL-5 and Eotaxin expression,the bone marrow suspension EOS count, CD34+ cell count and CD34 + /CCR3+ cell count in WBSYT group were decreased significantly (P<0. 01). Conclusions: Early intervention treatment can restrain anaphylaxis, inflammatory response of peripheral blood and airway in asthmatic mice by wenbu shenyang tang. Prevention taking wenbu shenyang tang may restrain anaphylaxis, differentiation CD34 + progenitor cells into EOS cells, change internal environment of marrow cavity in mice, and reduce release and gather of inflammatory factor. Reference citation:Yang Junchao,Zhao Wei, WangYuan,et al. Effect on EOS Differentiation of Progenitor Cell in Asthmatic Mice by the Intervention of Wenbu Shenyang Tang[ J]. China Journal of Chinese Medicine,2013 ,28(5) ;68l -682.关键词
哮喘/温补肾阳汤/EOS/祖细胞分化/小鼠Key words
asthma/wenbu shenyang tang/EOS/differentiation of progenitor cell/mice分类
医药卫生引用本文复制引用
杨珺超,赵玮,王媛,周勇,贾仰民..温补肾阳汤早期干预对哮喘小鼠EOS祖细胞分化的影响[J].中医学报,2013,28(5):681-682,前插1,3.基金项目
浙江省中医药科技计划项目(编号:2008YA006) （编号:2008YA006）
