中医学报2013，Vol.28Issue(5)：686-687,2.
参葛颗粒对糖尿病大鼠视网膜超微结构的影响
Effect of Shenge Granule on Retinal Ultrastructure in Diabetic Rats
摘要
Abstract
Objective;To observe the influence of shenge granule on retinal ultrastructure in experimental diabetic rats. Methods:Model of diabetes rat were induced by alloxan with intraperitoneal injection,and then randomly divided them into model group( 11 rats,normal saline,2 mL), treatment group (11 rats, shenge granule,7. 5 g ·kg-1) and control group (11 rats, calcium dobesilate treatment, 175 mg· kg-1 ) ,and normal group(10 rats,normal saline,2 mL) ,once a day. Changes of blood sugar,urine sugar and the retinal ultra-structure of rats were observed under electron microscope. Results; The blood sugar, urine sugar in diabetic rats were higher than that of normal group(P <0. 05) ,the model group were the highest, treatment group were the lowest. Under electron microscope, nerve cells of the retina of diabetic rats in model group, apoptosis cells increased, glial filament shape, nerve fiber structure arranged dispersedly and mussily, showed a trend of gradually increasing, retinal ultrastructure of rats in treatment group significantly improved compared with the model group. Conclusion:Shenge granule can effectively control blood sugar levels in diabetic rats,improve the retinal ultrastructure. Reference citation:Ji Peng,Huo Qin,Hu Fengli. Effect of Shenge Granule on Retinal Ultrastructure in Diabetic Rats[ J] . China Journal of Chinese Medicine,2013,28(5) :686 -687.关键词
视网膜超微结构/参葛颗粒/糖尿病/大鼠Key words
retinopathy ultrastructure/ shenge granule/ diabetes/ rat分类
医药卫生引用本文复制引用
吉鹏,霍勤,胡凤丽..参葛颗粒对糖尿病大鼠视网膜超微结构的影响[J].中医学报,2013,28(5):686-687,2.基金项目
河南省科技攻关项目资助(编号:0524410020) （编号:0524410020）
