河南中医2013，Vol.33Issue(5)：681-683,3.
丹参酮ⅡA调控NF-κB通路抗动脉粥样硬化实验研究
Experimental Study of Tanshinone Ⅱ A in Regulation of NF-κB Pathway and Anti-atherosclerosis
摘要
Abstract
Objective: To observe the regulation effect of tanshinone Ⅱ A on vascular endothelial cell NF - κB of rabbits with atherosclerosis, and to investigate its anti-atherosclerosis effects and related mechanism. Methods; 24 white Japanese male rabbits were randomly divided into normal control group, model group, tanshinone ⅡA group, with 8 rats in each group. Normal control group was fed with normal diet, model group were fed a diet containing 0. 02% methionine and 1% cholesterol to make atherosclerosis animal model. Besides the high fat diet tanshinone Ⅱ A group were given gastric gavage of tanshinone Ⅱ A, while the normal control group and model group were given the same amount of physiological saline by gavage. Observation of serum lipid levels, p65 expression of aortic endothelial cell NF - κ B pathway and pathological changes of aorta. Results: Total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and triglyceride (TG) of rabbit serum of tanshinone ⅡA group decreased significantly, HDL - C increased significantly, there was significant difference ( P < 0. 05 ) compared with the model group; p65 expression of aortic endolhelial cell NF - κB pathway in tanshinone ⅡA group decreased obviously, there was significant difference (P<0. 05) compared with the model group; the pathological examination showed that aortic AS lesions in tanshinone Ⅱ A group significantly retarded. Conclusion: Tanshinone Ⅱ A can protect vascular endothelial pharmacology, its mechanism may be related with the inhibition of p65 expression of NF - κB pathway.关键词
动脉粥样硬化/丹参酮ⅡA/主动脉内皮细胞/NF-κB通路/大白兔Key words
atherosclerosis/ tanshinone Ⅱ A/ aortic endothelial cells/ NF - B pathway/ rabbits分类
医药卫生引用本文复制引用
王建新,沈晓君..丹参酮ⅡA调控NF-κB通路抗动脉粥样硬化实验研究[J].河南中医,2013,33(5):681-683,3.基金项目
河南省基础与前沿技术研究计划项目(编号:112300410051) （编号:112300410051）
郑州市科技创新团队资助项目(编号:121PCXTD520) （编号:121PCXTD520）
