实用临床医药杂志2013，Vol.17Issue(5)：29-32,4.DOI:10.7619/jcmp.201305008
血清高尔基体蛋白73在肝细胞肝癌早期诊断中的价值
Value of golgi protein73 in diagnosis of hepatocellular carcinoma
摘要
Abstract
Objective To explore serum golgi protein73 (GP73) in the diagnosis of hepato-cellular carcinoma(HCC). Methods Serum GP73 and Alpha- feto protein(AFP) were quantitatively detected in a total of 270 human subjects, including 57 patients with HCC,71 patients with cirrhosis, 82 hepatitis B virus(HBV) carriers and 60 healthy adults. The receiver operating characteristic curve(ROC),sensitivity and specificity of GP73 and AFP for HCC patients were calculated. Results The serum level of GP73 in patients with HCC was significantly higher than that in healthy controls (P < 0. 05). Although GP73 levels in HBV carriers and patients with cirrhosis were somewhat elevated, they were much lower than those in patients with HCC (P<0.05). Using 100.18 μg/L as a cut-off value, the sensitivity and specificity of GP73 for HCC were 86.0% and 93.9% , compared with 77. 2% and 91. 5% for AFP using 37. 05 μg/L as a cut - off value. The sensitivity and specificity of the combination of GP73 and AFP were 91. 2% and 92. 5% respectively. Moreover, the GP73 level was elevated in the serum of individuals with HCC who had AFP level less than 400 ug/L( 16/21,76.19 %)). Conclusion Higher level of GP73 can be found in the serum of patients with HCC than those without. GP73 maybe a good serum marker of the early diagnosis of HCC. The detection of GP73 combined with AFP can effectively improve the sensitivity of the diagnosis of HCC, and especially contributes to the diagnosis of HCC patients with AFP - negative.关键词
高尔基体蛋白73/甲胎蛋白/肝细胞肝癌/诊断Key words
golgi protein 73/ alpha-fetoprotein/ hepatocellular carcinoma/ diagnosis分类
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杨爱华,陆文,张维..血清高尔基体蛋白73在肝细胞肝癌早期诊断中的价值[J].实用临床医药杂志,2013,17(5):29-32,4.
