摘要
Abstract
Objective To investigate the relationship between uric acid and blood pressure in a physical examination population and explore the gender related differences. Methods We randomly selected 979 subjects aged 30 - 75 years in physical examination centre of Changzhou No. 1 People's Hospital. A standardized questionnaire was used to collect information on general information . Blood pressure, height, weight, waist, hip, heart rate, concentration of serum lipid, glucose and uric acid were measured. Subjects were divided into 4 groups according to their interquartile range of uric acid levels in general population, male group and female group: group Ql (general population: uric acid <228.3 μmol/L; male group: uric acid <280.0 μmol/L; female group: uric acid <204.1 μmol/L); group Q2: (general population; 228.3 μmol/L ≤ uric acid < 284.2 μmol/L; male group: 280.0 pmol/L ≤ uric acid < 331.9 μmol/L; female group: 204.1 μmol/L ≤ uric acid <246.6 μmol/L); group Q3: (general group: 284.2 μmol/L ≤ uric acid <348.7 μmol/L; male group: 331. 9 μmol/L ≤ uric acid <383. 3 μmol/L; femal group: 246. 6 μmol/L ≤uric acid < 294. 9 μmol/L); group Q4: (general group: uric acid ≤ 348. 7 μmol/L; male group: uric acid ≤ 383.3 μmol/L; female group: uric acid ≤ 294.9 μmol/L). Results ①After being adjusted for regular risk factors, systolic blood pressure (for general population: P = 0.024; for female group: P - 0.023) and mean arterial pressure (for general population: P=0.0018; for female group: P - 0.025) were associated with serum uric acid levels, while diastolic blood pressure and pulse pressure were not related to serum uric acid levels both in general population and female group (P>0.05). In male group, none of the blood pressure indices was related to uric acid levels (P>0.05). ②Logistic regression analysis revealed that the prevalence of hypertension in Q4 group increased by 58.5% compared with that in Q1 in the female group (95% confidence interval: 12.9% - 22.4% ) , while in the male group, there was no statistical significance. In the total population, after further adjustment for gender, the prevalence of hypertension in Q4 group increased by 56.3% compared with that in Ql group (95% confidence interval: 25.6% - 94.5%). Conclusion Serum uric acid level was associated with systolic blood pressure, mean arterial pressure and prevalence of hypertension which was dependent on gender differences.关键词
血清尿酸/血压/性别Key words
serum uric acid level/ blood pressure/ gender分类
医药卫生
