实用临床医药杂志2013，Vol.17Issue(7)：88-90,3.DOI:10.7619/jcmp.201307029
帕瑞昔布用于食道癌根治术后镇痛的临床研究
Analgesic effect of parecoxib on patients undergoing radical resection of esophagus cancer
摘要
Abstract
Objective To investigate the effect of parecoxib on postoperative pain and mediastinum hemorrahage lead flow in patients undergoing radical resection of esophagus cancer. Methods Sixty-eight patients scheduled for radical resection of esophagus cancer were randomly allocated to parecoxib group (Group T, n = 34) and Control group (Group C, n = 34). A dose of 40 mg parecoxib was administered i. v 15 min before surgery in Group T, while the same dose of saline was administered in Group C. All patients were performed general anesthesia with left double-lumen tube intubated. All patients were treated with PCIA post-operatively (sufentanyl 2. 5 μg/kg + tropisetron 5 mg + normal saline/100 mL). Analgesic effect was evaluated by visual analog scale (VAS) 2, 6, 12, 24, 48 h after surgery, and the mediastinum hemorrahage lead flow 24,48h after surgery was observed. Results There was no significant difference between VAS at rest at every time point postoperatively in the two groups, while the VAS was significantly higher in the control group than in parecoxib group when coughing occurs. There was no significant difference between the mediastinum hemorrahage lead flow 24,48h after surgery in the two groups. Conclusion Pre-operative parecoxib administration can improve analgesic effect after radical resection of esophagus cancer, meanwhile it does not increase the mediastinum hemorrahage lead flow.关键词
帕瑞昔布/食道癌根治术/视觉模拟评分(VAS)/纵膈引流量Key words
parecoxib/ radical resection of esophagus cancer/ VAS/ mediastinum hemorrahage lead flow分类
医药卫生引用本文复制引用
季方兵,姚凤珍,郭松青,崔苏扬..帕瑞昔布用于食道癌根治术后镇痛的临床研究[J].实用临床医药杂志,2013,17(7):88-90,3.
