临床口腔医学杂志2013，Vol.29Issue(4)：231-233,3.DOI:10.3969/j.issn.1003-1634.2013.04.016
龈沟液中IL-1β与2型糖尿病和牙周病相关性的研究
The research of correlation among IL-1β in gingival crevicular fluid and type 2 diabetes, periodontal diseases
摘要
Abstract
Objective:To compare the different level of IL-1β in gingival crevicular fluid(GCF)among type 2 diabetes mellitus patients (DM), type 2 diabetes mellitus with periodontal diseases patients (DM&AP) and periodontal diseases patients (AP), we investigated the relationship between concetration of HbAlc and IL-1β in DM and DM&AP. Method: GCF were collected by filter strips.DM,DM & AP.AP patients and normal control group of 30 patients in each were included in this study. Their IL-1β were measured by ELASA, HbAlc in DM and DM&AP were detected by High Performance Liquid Chromatography. Result:The diabetics, diabetics with periodontal diseases and periodontal diseases patients had higher GCF and IL-1β than normal control group (P <0.05). The diabetics with periodontal diseases and periodontal diseases patients had higher GCF than the diabetics group (P <0.05). The diabetics with periodontal diseases had higher IL-1β than the diabetics group and periodontal diseases patients (P <0.05). Conclusion: The diabetics and diabetics with periodontal diseases patients have higher IL-ip than normal. Long-term hyperglycemia causes diabetic patients susceptible to periodontal disease. So diabetic patients should highly concerned about periodontal health as they control blood suger.关键词
白细胞介素-1β/2型糖尿病/牙周病/糖化血红蛋白Key words
Interleukin-1β/ type 2 Diabetes mellitus/ periodontal disease/ Glycosylated hemoglobin分类
医药卫生引用本文复制引用
张兰,丁岩,邓晓红,宋健玲..龈沟液中IL-1β与2型糖尿病和牙周病相关性的研究[J].临床口腔医学杂志,2013,29(4):231-233,3.基金项目
陕西省自然科学基金项目(2002C245) （2002C245）
