临床神经病学杂志2013，Vol.26Issue(2)：127-129,3.
阿托伐他汀对脑梗死患者血脂、颈动脉内-中膜厚度及复发率的影响
Influence of Atorvastatin on blood lipids, carotid intimal medial thickness and recurrence rate in cerebral infarction patients
陈霓红 1周俊山 1蒋伏平 1黄清 1徐梦怡 1周峰1
作者信息
- 1. 210006 南京医科大学附属南京医院(南京市第一医院)神经内科
- 折叠
摘要
Abstract
Objective To study the influence of Atorvastatin on blood lipids, carotid intimal medial thickness (IMT) and recurrence rate in cerebral infarction patients. Methods Fifty-nine cerebral infarction patients with hyperlipidemia and carotid artery atherosclerosis were randomly divided into Atorvastatin group (29 cases) and control group (30 cases). All the patients in the two groups were received conventional treatment for cerebral infarction. The patients in the Atorvastatin group were added with a daily dose of 20 mg Atorvastatin for 12 months. Serum lipid levels and IMT which was obtained by color flow Doppler sonography were checked respectively before treatment and at 3, 6 and 12 months after treatment. The cases of recurrent cerebral infarction were count after the treatment of 12 months. Results The levels of blood cholesterol (TC) , the level of blood low density lipoprotein ( LDL) in Atorvastatin group at each time points were significantly lower than those before treatment and in the control group (all P< 0.01). At 12 months after treatment, the level of blood high density lipoprotein (HDL) in the Atorvastatin group was significantly higher than those before treatment and in control group ( all P < 0. 05 ) . At 6 and 12 months after treatment, the carotid IMT in Atorvastatin group were significantly thinner than those before treatment and control group(P<0. 05 — 0. 01). At 12 months after treatment, the carotid IMT in control group was significantly higher than that before treatment (P<0. 05). At 12 months after treatment, there was no recurrent cerebral infarction in the Atorvastatin group, meanwhile there were 3 cases of recurrent cerebral infarction in control group (10% ). Conclusion Atorvastatin can significantly reduce the levels of blood TC and LDL-C. The long-term treatment with Atorvastatin can effectively reduce carotid IMT and recurrence rate of cerebral infarction.关键词
阿托伐他汀/脑梗死/血脂/颈动脉内-中膜厚度Key words
Atorvastatin/cerebral infarction/blood lipids/carotid intimal medial thickness分类
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陈霓红,周俊山,蒋伏平,黄清,徐梦怡,周峰..阿托伐他汀对脑梗死患者血脂、颈动脉内-中膜厚度及复发率的影响[J].临床神经病学杂志,2013,26(2):127-129,3.
