中国临床保健杂志2013，Vol.16Issue(2)：148-150,后插2,4.DOI:10.3969/J.issn.1672-6790.2013.02.014
局部进展期胃癌术后放化疗与单纯化疗的对比研究
Comparision of postoperative radiochemotherapy with chemotherapy alone in the treatment of locally advanced gastric cancer
摘要
Abstract
Objective To invesligale the efficacy and lolerance of posloperalive concurrent chemoradiothera-py ( RCT) and chemotherapy ( CT) for gaslric cancer. Methods The 76 palienls who met the following enrolled cri-teria were included in the study: underwent curalive gaslreclomy and D2 lymphadeneclomy , palhologically slaged as Ⅱ -Ⅳ- 31 cases were assigned to concurrenl chemoradiotherapy group and 45 cases were in chemotherapy group. Then, 2 or 3 — year survival rale and loxicily of the two groups were evaluated. Results The 2 — year survival rales for RCT and CT groups were 85. 5% and 72. 3% respectively, 3 — year survival rales for RCT and CT groups were 69. 2% and 40% ( P = 0. 045) respectively. The 2 — year recurrence-free survival rales( RFS) for RCT and CT groups were 74. 7% and 48. 6% respectively, 3 — year recurrence-free survival rales for RCT and CT groups were 49. 8% and 30. 1% ( P = 0. 041) respectively. The incidence of grade 3 hemalological toxicily was20. 7% vsl7. 1% ( P =0. 373) , and gastrointestinal toxicily was93. 1 % vs 63. 4% ( P = 0. 034) . Conclusions The chemotherapy combined with con-formal intensity-modulated radiotherapy can improve survival rale and their prognosis.关键词
胃肿瘤/放射疗法/抗肿瘤联合化疗方案Key words
Stomach neoplasms/Radiotherapy/Anloneoplastic combined chemotherapy protocols分类
医药卫生引用本文复制引用
冉晶晶,张红雁,罗文广,刘伟..局部进展期胃癌术后放化疗与单纯化疗的对比研究[J].中国临床保健杂志,2013,16(2):148-150,后插2,4.基金项目
安徽省科技攻关项目(08010302190) （08010302190）
