农业生物技术学报2013，Vol.21Issue(4)：464-474,11.DOI:10.3969/j.issn.1674-7968.2013.04.012
拷贝数变异的研究方法及其在畜禽中的研究进展
Research Measures for Copy Number Variation and its Research Progress in Livestock and Poultry
摘要
Abstract
Copy number variation (CNV) is an important source of genetic variation complementary to single nucleotide polymorphism (SNP). It has been shown not only relating with disease susceptibility and developmental abnormality, and also with appearance characteristics and economically important traits. Combined using the SNP and CNV will provide new research ideas for dissecting the molecular mechanism and genetic basement of complex traits of livestock and poultry. Additionally, CNV would have broad application in marker assistant selection in breeding of livestock and poultry. Genome-wide CNV discovery approaches include array comparative genome hybridization (CGH), high dense SNP chips and newly developed genome re- sequence based on high- throughput sequencing technologies. Since 2008, using hybridization- based chip and sequencing- based technologies, a series of studies have been performed to construct CNV maps in every livestock and poultry. In the present article, we summarized the detection measures to identify genome-wide CNV, methods for genotyping the detected CNV, and the considerable advances of CNV in livestock and poultry. It will provide useful information for researchers engaged in the field.关键词
拷贝数变异/遗传变异/研究方法/畜禽Key words
Copy number variations/ Genetic variation/ Research measures/ Livestock and poultry引用本文复制引用
王继英,郭建凤,张大龙,王彦平,陶海英,武英..拷贝数变异的研究方法及其在畜禽中的研究进展[J].农业生物技术学报,2013,21(4):464-474,11.基金项目
山东省农业良种工程(No.2010LZ013-01)、国家现代农业产业技术体系(No.CARS-36)和山东省农业产业技术体系生猪创新团队建设项目 （No.2010LZ013-01）
