西北师范大学学报（自然科学版）2013，Vol.49Issue(2)：84-89,6.
中药复方对麻黄素成瘾小鼠大脑额叶结构的影响
Effect of Chinese medicine compound on frontal lobe structure of ephedrine addiction mice
摘要
Abstract
To research the effect of Chinese medicine for ephedrine addiction animal, and to develop no side effects Chinese herba preparation for addiction effect, 120 filial mice are intraperitoneally injected with escalation doses (2. 0,3.0,4. 0g·L-1) of ephedrine or the same amount of saline to establish ephedrine addiction animal modle, then are given a gavage of saline or Chinese medicine for withdrawal respectively. The samples are collected at 5, 10 and 15 d, the body weight and the brain weight are measured, in addition, the changes of frontal lobe structure are observed by optical microscopy. Results show that the body weight and the brain weight of mice in the experimental control group are both lower than that in the natural control group in 5,10 and 15 d after injecting ephedrine, while that of the Chinese medicine group is higher than the experimental control group. The thickness of mice frontal lobe of the experimental control group is thinner than that of the the natural control group, that of the Chinese medicine group is thicker than the experimental control group. The structure of mice frontal lobe is damaged in varying degree:cell migration, number reducing, stratification not clear, shape changing, the situation is improved in the Chinese medicine group.关键词
麻黄素/小鼠/大脑额叶/中药复方Key words
ephedrine/ mice/ frontal lobe/Chinese medicine分类
医药卫生引用本文复制引用
俞诗源,陈琛..中药复方对麻黄素成瘾小鼠大脑额叶结构的影响[J].西北师范大学学报（自然科学版）,2013,49(2):84-89,6.基金项目
甘肃省自然科学基金计划项目(1107RJZA141) （1107RJZA141）
兰州市社会发展项目(2010-127) （2010-127）
