医药导报2013，Vol.32Issue(5)：600-602,3.DOI:10.3870/yydb.2013.05.014
白念珠菌细胞壁β-葡聚糖对小鼠免疫功能的影响
The Effect of Beta-glucan from Cell Wall of Candida albicans on Immunological Function in Mice
摘要
Abstract
Objective To study the effect of β-glucan extracts from the cell wall of Candida albicans on immunosuppressive mice induced by cyclophosphamide ( CTX).Methods The immunosuppressive model was established by intraperitoneal injection of CTX.Three kinds of β-glucan were extracted from the cell wall of Candida albicans.The effects of p5-glucan on leukocytes were studied by cell counting and histopathological observation.Results Compared with the control group, three kinds of Candida albicans β-glucan raised the number of leukocytes, neutrophilic granulocytes and monocytes in the peripheral blood.The spleen index in all groups was increased, and so was megakaryocyte in spleen and marrow.Conclusion Candida albicans β-glucan, specially insoluble β-glucans is a kind of promising immunomodulator that can increase the leukocyte counts in the peripheral blood.关键词
白念珠菌/β-葡聚糖/免疫调节药Key words
Candida albicans/ β-glucan/ Immunomodulator分类
医药卫生引用本文复制引用
宁莉,张敬伟,魏殿军..白念珠菌细胞壁β-葡聚糖对小鼠免疫功能的影响[J].医药导报,2013,32(5):600-602,3.
