医药导报2013，Vol.32Issue(5)：660-663,4.DOI:10.3870/yydb.2013.05.036
奥沙利铂长循环脂质体制备工艺优选
Technological Optimization on Preparation of Oxaliplatin Long-circulating Liposome
摘要
Abstract
Objective To optimize technology on preparation of oxaliplatin long-circulating liposome.Methods The liposome was prepared by ethanol injection method.Orthogonal design was used to optimize the prescription and preparation.Encapsulate rate of the liposome was determined by high performance liquid chromatography.Results The optimum prescription was as follows: the quality ratio of lecithin to cholesterol was 5:1, the amount of oxaliplatin was 10 mg, and the concentration of polyethylene glycol 2000 was 0.05% , the average coating rate is (51.87±0.90)%.Conclusion The optimized formulation of PEG2000-conjugated oxaliplatin long-circulating liposome is reasonable, practicable and stable.关键词
奥沙利铂/脂质体/长循环/聚乙二醇2000Key words
Oxaliplatin /Liposomes/ Long-circulating /PEG2000分类
医药卫生引用本文复制引用
祁梅芳,李俊丽,刘小平,刘阳,阳柳..奥沙利铂长循环脂质体制备工艺优选[J].医药导报,2013,32(5):660-663,4.基金项目
中央高校基本科研业务费专项资金资助(Whut-2011-IV-023) （Whut-2011-IV-023）
武汉市青年科技晨光计划项目资助(201271031391) （201271031391）
