首页|期刊导航|中国临床药理学杂志|非洛地平缓释片在中国健康男性的生物等效性

非洛地平缓释片在中国健康男性的生物等效性OA北大核心CSCDCSTPCD

Bioequivalence of felodipine extended release tablets in Chinese healthy male subjects

中文摘要英文摘要

目的 评价2种非洛地平缓释片在健康中国男性人体的生物等效性.方法 用双交叉设计,24名健康男性受试者随机分为2组,单剂量口服非洛地平缓释片试验药物或对照药物5mg,用液相色谱-串联质谱法测定血浆非洛地平血药浓度,用DAS 2.0软件计算药代动力学参数.结果 试验药物与对照药物的Cmax分别为(2.15±1.37),(1.67±0.87) ng·mL-1;Tmax分别为(5.40±3.42),(5.85±4.84)h;t1/2分别为(16.51±5…查看全部>>

Objective To evaluate the bioequivalence of the two felo-dipine extended release tablets in Chinese healthy male subjects. Methods A single oral dose 5 mg of test and reference felodipine extended release tablets were given to 24 subjects according to an open randomized crossover design. The concentrations of felodipine in plasma were determined by LC - MS/MS. The pharmacokinetic parameters were calculated and the bioequivalence was compared by DAS 2. 0. Res…查看全部>>

许俊羽;赵侠;孙严彤;顾景凯;王梓凝;张冬梅;周颖;梁雁;崔一民

医药卫生

非洛地平液相色谱-串联质谱法生物等效性

felodipineLC - MS/MSbioequivalence

《中国临床药理学杂志》 2013 (3)

189-191,3

评论

您当前未登录!去登录点击加载更多...