中国临床药理学杂志2013，Vol.29Issue(3)：192-195,4.
头孢噻利不同剂量单次静滴在中国健康人群的血清杀菌活性
Serum bactericidal activity of different single intravenous doses of cefoselis in Chinese healthy volunteers
摘要
Abstract
Objective To compare the serum bactericidal activity (SBA) of different single intravenous doses of cefoselis(CFSL) in Chinese healthy volunteers. Methods The minimal inhibitory concentration ( MIC ) of cefoselis against Enterobacter cloacae not producing enzyme / producing AmpC enzyme, and methicillin susceptible Staphylococcus au-reus (MSSA) were determined by microdilution method. Twelve healthy volunteers were given three single intravenous doses of cefoselis respectively and blood sample were collected at 0. 5 h (peak) and 5,8,12 h ( valley) after infusion. The SB A was determined by broth microdilution method, and the rate of SBA were analysed. Results The three clinical pathogens were sensitive to cefoselis. The SBA of three clinical pathogens were all > 1: 1 ~ 1: 64 for o. 5 h (peak) after cefoselis infusion. The range of SBA for Enterobacter cloacae producing AmpC enzyme and MSSA increased slightly with the increase of doses. At the peak of curve, the SBA median of different dose groups for Enterobacter cloacae producing AmpC enzyme were statistically significant ( P < 0. 05). The SBA median of different dose groups for Enterobacter cloacae not producing AmpC enzyme and MSSA were not statistically significant ( P > 0. 05 ) . The SBA median of different dose groups for same kind of pathogens were not statistically significant (P > 0. 05). The percentages of SBA were assessed with chi - square statistics. The percentages of SBA ≥ 1: 8 ( peak) for three clinical pathogens were not statistically significant ( P > 0. 05 ). Some of the percentages of SBA ≥ 1: 1 ( valley and other time ) for Enter-obacter cloacae not producing AmpC enzyme and MSSA were statistically significant (P < 0. 05 ). Conclusion The strong in vivo antibacterial activity of cefoselis to Enterobacter cloacae not producing enzyme / producing AmpC enzyme, Enterobacter cloacae producing AmpC enzyme and MSSA, and there will be a better clinical efficacy as predicted.关键词
头孢噻利/阴沟肠杆菌/产AmpC酶/杀菌活性Key words
cefoselis/Enterobacter cloacae/produce AmpC enzymes/bactericidal activity分类
医药卫生引用本文复制引用
白艳,王瑾,蔡芸,梁蓓蓓,白楠,梅和坤,曹江,王睿..头孢噻利不同剂量单次静滴在中国健康人群的血清杀菌活性[J].中国临床药理学杂志,2013,29(3):192-195,4.基金项目
十二五国家重大科技专项基金资助项目(2012ZX09303004-002) （2012ZX09303004-002）
