中国全科医学2013，Vol.16Issue(11)：1210-1212,1215,4.DOI:10.3969/j.issn.1007-9572.2013.04.042
原发性高血压患者血压水平及血压变异性与超敏C反应蛋白的关系研究
Relationship of High Sensitive C-reactive Protein with Blood Pressure and Blood Pressure Variability in Patients with Essential Hypertension
摘要
Abstract
Objective To explore the relationship high sensitive C - reactive protein ( hs - CRP ) with blood pressure ( BP ) and BP variability ( BPV ) in patients with essential hypertension. Methods A total of 178 hypertensive outpatients and inpatients of our hospital between October 2011 and June 2012 were included. 24 h ambulatory blood pressure monitoring was conducted. Plasma level of hs - CRP, fasting blood glucose and lipids were also examined. Patients were grouped into quartiles according to hs - CRP level. Average BP and standard deviation ( SD, as the index of BPV ) in different time intervals ( 24 -hour, daytime, nighttime ) were compared among four groups. The correlations between hs - CRP and BP or BPV were analyzed with multiple linear regression. Results Compared to the lowest quartile of hs - CRP, systolic and diastolic BPV were significant higher in the highest quartile during the nighttime ( P <0. 05 ). By contrast, there was no difference in mean BP among the hs - CRP quartile groups during any of the time periods ( P > 0. 05 ). Multiple linear regression models revealed that nighttime SBP - SD ( β = 0. 228 , P < 0. 01 ) and high density lipoprotein cholesterol (β= - 0. 190, P < 0. 05 ) were significantly related to hs - CRP. Conclusion Hs - CRP is closely related with BPV in hypertensive patients, suggesting that inflammation may be one of the mechanisms underlying the link between BPV and target organ damage.关键词
高血压/血压变异性/炎症/C反应蛋白质/血压测定Key words
Hypertension/ Blood pressure variability/ Inflammation/ C - reactive protein/ Blood pressure determination分类
医药卫生引用本文复制引用
徐燕,王梦琳,高旭光..原发性高血压患者血压水平及血压变异性与超敏C反应蛋白的关系研究[J].中国全科医学,2013,16(11):1210-1212,1215,4.
