摘要
Abstract
Objective To explore the association between serum alanine aminotransferase ( ALT ) level and diabetes mellitus ( DM ) - related indicators in the high - risk population. Methods Ninety - three cases undergoing a 75 g oral glucose tolerance test ( OGTT ) in our hospital between December 2009 and June 2012 were selected. They were divided into three groups: normal glucose tolerance ( NGT) group ( n =31 ), impaired glucose tolerance ( IGT ) group ( n = 30 ) and type 2 DM ( T2DM ) group ( n = 32 ) according to the condition of their glucose metabolism. DM - related indicators and serum ALT level in each group were recorded and compared. Correlation analysis was conducted between each indicator and serum ALT level for each group. All subjects were divided into four groups according to serum ALT levels : the first quartile group ( ALT < 15 U/L), the second quartile group ( ALT 15 ~20 U/L), the third quartile group ( ALT 21 ~ 30 U/L), and the fourth quartile group ( ALT > 30 U/L). T2DM prevalence in each group was calculated. Logistic analysis was used to evaluate the relationship between serum ALT level and the prevalence of T2DM. Results Significant differences in serum ALT levels were observed between each two of the NGT group ( 18 ± 11 ) U/L, IGT group ( 25 ± 16 ) U/L, and T2DM group ( 31 ± 20 ) U/L ( P < 0. 05 ). Serum ALT level was positively correlated with body mass index ( BMI ), waist circumference, systolic blood pressure ( SBP ), diastolic blood pressure ( DBP ), fasting plasma glucose ( FPG ), 2 h postprandial glucose ( 2 h PG ), fasting insulin ( FINS ), 2 h postprandial insulin ( 2 h INS ), glycosylated hemoglobin ( HbA1c ), triglyceride ( TG ), low - density lipoprotein cholesterol ( LDL - C ), and insulin resistance index ( HOMA - IR ) ( P <0. 05 ), while negatively correlated with gender, age, and high -density lipoprotein cholesterol ( HDL - C ) ( P <0. 01 ). The SBP, 2 h INS, TC, and LDL - C had no correlation with serum ALT level ( all P > 0. 05 ), and the correlation with other indicators weakened after controlling the influence of BMI and waist circumference. The T2DM risk of patients in the fourth quartile group was 2. 16 times that of the patients in the first quartile group after adjusting for gender, age, BMI, and waist circumference. The T2DM risk of the fourth group was 1. 72 times that of the first group after adjusting for TC, TG, LDL - C, HDL - C, and HOMA - IR. Conclusion T2DM patients have the highest level of serum ALT, followed by IGT patients and healthy population. Serum ALT level might be associated with the occurrence of T2DM independent of obesity, serum lipids, and secretion function.关键词
丙氨酸氨基转移酶/糖调节异常/糖尿病/胰岛素抵抗Key words
Alanine aminotransferase/ Impaired glucose regulation/ Diabetes mellitus/ Insulin resistance分类
医药卫生
