帖晓静 1田永巍 1高岭 1李宁 1刘培杰 1徐志巧1
作者信息
摘要
Abstract
Objective To evaluate the efficacy of capecitabine combined with radiotherapy on rectal cancer. Methods Fifty - two patients with locally advanced rectal cancers admitted from June 2007 to June 2010 were divided, according to treatment, into groups control ( n = 25 ), study ( n = 27 ). Control group given only radiotherapy, study group combined with capecitabine. The overall response rate ( ORR ), adverse reaction, carcinoembryonic antigen ( CEA ), progression - free survival ( PFS), 1 - , 2 -year survival rate were observed in 2 groups. Results ORR was 16/25 in control group, 24/27 in study group, the difference was significant ( x2=4. 530, P = 0. 049 ); The main adverse reactions were myelosuppression and diarrhea. No difference was noted in CEA level between 2 groups before or after treatment ( P > 0. 05 ), but there was between pre - and post - treatments in the two groups ( P < 0. 05 ). PFS was ( 20. 4 ± 1. 1 ) months in control group, ( 27. 0 ± 1. 4 ) months in study group, the difference was significant ( t = 3. 795, P < 0. 05 ). The 1 - year survival rate was 25/25 in control group, 27/27 in study group, the difference was not significant ( x2=0. 000, P >0. 05 ), the 2 -year survival rate was 21/25 in control group, 25/27 in study group, the difference was significant ( x2=0.939, P > 0. 05 ). By Person correlation analysis , CEA level was negatively correlated with PFS ( r = - 0. 329, P= 0. 017 ), not with OS ( r = - 0. 185 , P = 0. 189 ). Conclusion The effect of capecitabine combined with radiotherapy is superior to that of simple radiotherapy. CEA level can be one of the indicators predicting the effects of capecitabine with radiotherapy.关键词
卡培他滨/放射疗法/直肠肿瘤/癌胚抗原Key words
Capecitabine/ Radiotherapy/ Rectal neoplasms/ Carcinoembryonic antigen分类
医药卫生
